Your email address will not be published. API quota exceeded. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. And we need them to stay off the market. It received FDA approval in 2016. She's on valium and all her blood work is perfect, how long should tremors last for? How long does Simparica trio stay in a dogs system? Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. Based on official information, simparica is for treatment related to the flea and tick. Against Amblyomma americanum, SIMPARICA TRIO demonstrated 99.4% effectiveness 72 hours after treatment of existing infestations, and maintained 98.4% effectiveness 72 hours after re.infestation for at least 28days. Not only does it protect against fleas but also offers protection against 5 different types of ticks. How long do side effects last from Simparica trio? Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. Sarolaner has insecticidal and acaricidal properties that work for the duration of a month. Therefore, it is essential to consult a veterinarian before giving Simparica to your animal. Luckily, the study found the drug is highly effective. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active. It is given once a month. Each tablet size is available in packages of one, three, or six tablets. Bernadette Dunham, D.V.M., Ph.D., Director, Center for Veterinary Medicine at the FDA, This site is protected by reCAPTCHA and the Google. This powerful and potent chewable cure is a multi-spectrum treatment that helps protect dogs from heavy flea and tick infestations. SIMPARICA TRIO contains the S-enantiomer of sarolaner. In its annual Animal Health Awards, IHS Markit Connect (formerly known as Animal Pharm) honored Zoetis' Simparica Trio as the Best New Companion Animal Product for 2020. Total waste of time. 4 Winter Tips for Keeping Your . Nexgard (active ingredient afoxolaner) and Bravecto (fluralaner) were approved in the US in late 2013 and early 2014. Simparica. The chemical name for moxidectin is (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino) milbemycin B. Pyrantel belongs to a family classified chemically as tetrahydropyrimidines and the chemical name is (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine 4,4 methylenebis [3-hydroxy-2-naphthoate](1:1). Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . SIMPARICA TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. The most common symptoms of flea and tick medicine poisoning in cats include: Tremors/muscle twitching/trembling. Things like: It is acceptable to use Simparica in conjunction with commonly prescribed vaccines, parasiticides, and other medications. Cuddles is with me 24/7 since I am currently homebound. That means most dogs will take their dose. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. The terminal half.lives were similar after oral and IV dosing for both sarolaner (12 days) and moxidectin (11days). If you prefer online orders, you can order it on Chewys online pharmacy. This particular product is the advanced version of the currently existing Simparica chewables and is believed to become the number one flea, tick, and heartworm oral treatment in a few months time. Whether you are looking for a puppy or just some advice, World Dog Finder is here to provide you with everything you and your dog will ever need. Seizures had been mentioned as a possible side effect of Simparica and the other three drugs, but only in very small print, sometimes on the back of the boxes and in the lengthy product inserts . The Simparica Trio tablet is a good solution to all problems. Nevertheless, some were documented. Simparica Chewables for Dogs 44.1-88 lbs (Green) 3 Pack is of $38.07 6 Pack is of $62.36. The side effects of these flea and tick drugs include ataxia, diarrhea, loss of appetite, lethargy, skin irritation, tremors and seizures. Direction and dosage information for Simparica TRIO. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. The study concluded that: Sarolaner was safe, achieved 100% reduction in the numbers of S. scabiei detected and resulted in marked improvement of the clinical signs of sarcoptic mange in dogs following two monthly oral administrations., The study stated that with a monthly dosing schedule, , sarolaner could provide a very convenient and effective treatment option for dogs suffering from mite infestations.. Afoxolaner is . Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Simparica Trio is also effective against 5 different types of ticks, including American dog ticks, Lone star ticks, and deer ticks. Your veterinarian will most likely prescribe flea control measures, a treatment to control itchiness and a possible secondary skin disease in hypersensitive dogs. In contrast, one of three dogs (33%) that were started on immuno-suppression before day 30, and all four dogs (100%) that were immuno-suppressed for the entire study had live mites on day 60.. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. The is why she lived so long. Also read our comparison of the two products! Seizures in dogs . Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating fleas. Although the medicine is effective, it is not a cure-all for heartworm disease and should only be used when absolutely necessary. There are two main types of heartworm medications available on the market for dogs: oral and topical. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. In well-controlled laboratory studies, SIMPARICA TRIO demonstrated 98.9% effectiveness against an existing infestation of Amblyomma maculatum, Ixodes scapularis, Rhipicephalus sanguineus, and Dermacentor variabilis 48 hours post-administration and maintained 90.4% effectiveness 48 hours after re-infestation for at least 28 days. Things You Need To Know About Combining Flea Treatments, Droncit v/s Drontal Plus v/s Revolution : Best Dewormer Online, Eliminates as many as five types of tick species including gulf coast ticks, American dog ticks, lone star ticks, deer ticks, and brown dog ticks, Effective in eliminating heavy flea infestations, Acts as a powerful monthly heartworm preventative, Treats and controls roundworms and adult hookworms, Flavored chewable that help in an easy dosing. Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, five types of ticks, fleas, roundworms and hookworms, all in one monthly chewable. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Pyrantel Pamoate was first approved in 1977 for the treatment and . However, we must note that vets do not recommend Simparica in dogs with seizures because of the high risk of neurologic adverse reactions. When given correctly, Simparica kills fleas within three hours. Approved by FDA under NADA # 141-452. She was a little, precious toy poodle. Moxidectin acts by interfering with the chloride channel.mediated neurotransmission in the parasite. If your dog has numerous ticks feeding off him, severe anemia and tick paralysis can result. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. Use with caution in dogs with a history of seizures or neurologic disorders. What are the side effects of enalapril in dogs? Luckily, dogs treated with Simparica had mild side effects that were gone 24 hours after the initial administration. Ever since, the controversy around these products has been increasing on a continuous basis. If a dose is missed, administer SIMPARICA and resume a monthly dosing schedule. The fleas and ticks begin to die when their nervous systems are stimulated. What are the side effects of temaril p for dogs? Simparica Trio does require a prescription. SIMPARICA can be offered by hand, in the food, or administered like other tablet medications. Simparica Trio is given once a month, so your dog will need it every month. NexGard flea and tick pills, in fact, the very first chewable pest medicine for dogs, making it easy for dogs to get protected against pests each month. World Dog Finder lets you find expert advice regarding dog breeds, dog care, and the latest news from the dogs world. The therapeutic dose of the isoxazoline in Simparica is between 2 to 4 mg/kg. How long does it take for Simparica Trio to work? These drugs are supposed to protect our pets by killing the pests that invade the lives of animals. Mar 1, 2023. Dogs in the control group received placebo. (sarolaner, moxidectin, and pyrantel chewable tablets). The all-new Simparica Trio chewable treatment is extremely safe for dogs of all breeds, except the following: Puppies younger than 8 weeks of age or weighing less than 2.8lbs. Although the product is available only on prescription, it is still a powerful treatment for heartworm. It is best to discuss them with your veterinarian before using it. Simparica, Bravecto, NexGard & Seizures. Ticks are just as dangerous, and certain types of ticks transmit Lyme disease, Rocky Mountain spotted fever, Q-Fever, and Lyme Disease. The following are filed under Simparica benefits: Now that we know a little bit more about Simparica and what it does, lets find out what its used for when it comes to our beloved dogs. Simparica Trio is a chewable tablet for dogs. It also doesnt affect your dogs food intake, so your pup can take it at any time without difficulty. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of . Nevertheless, some were documented. In two separate, well-controlled laboratory studies, SIMPARICA TRIO was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. Hi, I'm Kelly. Let us now look at possible side effects when administering Simparica. Dogs in the control group received placebo. But, sarolaner works quicker and lasts longer than afoxolaner. Heres what you should know if you are considering this medication for your dog. Elimination of roundworms (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) was demonstrated in well-controlled laboratory studies. On Aug. 10, I gave Zeke his monthly dose of Simparica (80 mg flea and tick treatment, chewable). K9 Advantix II A Quick Look. I love that little dog, I want to thank you for adding me to your group. 1x 20mg tablet for 11.1 to 22 pounds. Interceptor Plus has a 96.6% overall acceptability. NexGard. This combination of three medicines provides fast results for prevention and treatment of parasitic problems. Abnormal neurological effects were observed at dosages between 12 to 24 mg/kg, 3 to 5 . To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. SIMPARICA (sarolaner) Chewables are available in six flavored tablet sizes: 5, 10, 20, 40, 80, and 120 mg. Each tablet size is available in color-coded packages of one, three, or six tablets. Symptoms of Flea and Tick Medicine Poisoning in Dogs. Is a third Isoxazoline drug really necessary while the two older ones have not even been proven beyond doubt to be safe for our furkids? I just wish I would have known about this a couple weeks ago. Intestinal Nematode Treatment and Control: For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. Both products kill 100 percent of fleas within 24 hours. For moxidectin the Vss was 7.65 L/kg and CL was 26.6 mL/kg/hr. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Our Vet called Cuddles a miracle dog. If your dog has an existing history of seizures, consult your veterinarian before administering Simparica Trio. Is there a generic version of Simparica Trio? Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). No adverse effects were observed at the maximum exposure dose of 4 mg/kg. What Are the Side Effects of Simparica Trio for Dogs? The top three adverse events that have been observed in pets taking Simparica are vomiting, diarrhea and lethargy and the occurrence of these side effects are 1 in 10,000. Throughout her life Cuddles had liver disease, Cushing disease, pancreatitis, and the last few years, some kidney problems. As of September 21, 2018, the FDA began alerting pet owners and veterinarians of the potential neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. Does not require a prescription. KingsGuard2603 1 yr. ago. But what, I hear you ask, about the side effects? Sarolaner has fast and consistent efficacy for the full dosing period against fleas and multiple species of ticks. Lyme disease is not the only tick born pathogen that can be contracted during a tick infestation. Treatment with SIMPARICA TRIO may begin at any time of the year. Canine wipes or damp paper towels can be used to remove the excrement. This petition starter stood up and took action. It can be administered to puppies and dogs at least eight weeks of age. 2016, it had been on the market for only 4 months. 1x 10mg tablet for 5.6 to 11 pounds. Cuddles was fine and tests were great that morning. In a well-controlled US field study consisting of 246 dogs administered SIMPARICA TRIO and 119 administered an active control, no dogs treated with SIMPARICA TRIO tested positive for heartworm disease. 4 Those bites can also lead to infectious diseases. If you are not regular with doses, the effectiveness of the medication can be lowered. Puppies need protection from fleas and ticks too. Two dogs were removed from the sarolaner group when they were identified as being pregnant during the study.. Precautions. They will recommend a course of treatment, which is generally every four weeks throughout the year. One additional, placebo dog was withdrawn due to a transmissible venereal tumor. How Long For Dog To Get Better After Simparica Reactions. Based on the BudgetPetCare.com analysis, Simparica scores 4.5 out of 5 in vet ratings, which means it is a product frequently recommended by veterinarians. Without that data, it would be impossible to get FDA approval. Please do not give your dog any of these pills. What are the . In view of what had already been reported for its two sister drugs, it would be fair to assume that Simparica is going the same way. Simparica for dogs is a drug from the isoxazoline class. Her kidneys and liver had even improved, but she did have fleas. Pregnant, breeding, and lactating (research work regarding the safe use of Simparica Trio on such dogs is still going on as we speak). For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. What are the side effects of too little insulin in dogs? According to EMEA, Simparica was found to be well tolerated by animals treated with the recommended treatment dose of 24 mg sarolaner/kg bw. Simparica (sarolaner) came out in March 2016. The question Can Simparica Trio cause vomiting and diarrhea? It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Simparica TRIO Comparison | PetMedsCompare products. . That said, dog parents need to keep in mind that this drug remains in your dogs bloodstream for an extended period and there are plenty of other options when it comes to flea and tick control, like natural flea and tick products with essential oils. It remains 100 percent effective against adult fleas and weelies for 35 days. Slow-dissolving microspheres contain and prolong the effects of moxidectin-which redistributes from plasma to adipose tissue. We as dog-parents always remain updated with any new product in the market. It is FDA-approved for heartworm prevention and is safe to give to puppies as young as eight weeks old and weighing 2.8 pounds. This sensitivity is called flea allergy dermatitis. Sarolaner is a member of the isoxazoline class of parasiticides and the chemical name is 1-(5-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-H-spiro(azetidine-3,1-(2) benzofuran)-1-yl)-2-(methylsulfonyl)ethanone. Diagnosis is made by visual observation by a dog owner and veterinarian by slowly parting the dogs hair. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Ticks can survive from a few months to several years without food if they find themselves in the right environmental conditions. Simparica (Sarolaner (Simparica chewable tablets, Zoetis), is widely used by veterinarians for the treatment and prevention of flea and tick infestations in dogs. Although these products can and have been safely used in the majority of dogs and cats, pet owners should consult with their veterinarian to review their patients medical histories and determine whether a product in the isoxazoline class is appropriate for their pet.. Sarolaner is well tolerated in Collies with a deficient multidrug-resistance-protein 1 (MDR1 -/-) following single oral administration at 5 times the recommended dose. I had to take her to the emergency clinic. There are several reasons why veterinarians recommend Simparica Trio. reduced or absent menace, and or seizures. on 2022-06-28 by Kathy Auten Flag. The flea and tick activity resides in the chirally pure S-enantiomer, which was purified to alleviate potential off-target effects from the inactive enantiomer., In a head-to-head comparative in vitro assay with both afoxolaner and fluralaner, sarolaner demonstrated superior flea and tick potency. So, heres some good news for dog parents. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. As a chewable, it's best to administer Interceptor Plus in a manner that encourages your dog to chew, rather than to swallow without chewing. Simparica Trio provides 30-day protection, so it has to be given to dogs once each month. As with any drug, Simparica TRIO can cause some side effects. However, in the event of an overdose (3X or more the recommended dose), neurological effects (tremor, ataxia, convulsions) were observed. All three ingredients have their own special task which they handle to perfection. As of late, there are not many publications as to the toxicity of Sarolaner on the environment, or on pets. in dogs has been on the minds of many owners. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. In addition to being inexpensive, Simparica Trio is easy to administer because it only needs to be given once a month. While the medication is water-resistant, it is not suitable for dogs that swim. Use with caution in dogs with a history of seizures. A 10-year-old boxer named Blayz was given the anti-parasitic drug Simparica TRIO to treat a recurring case of heartworm in his dog. Simparica Trio is made up of three active ingredients Sarolaner, Pyrantel, and Moxidectin. What are the side effects of clindamycin for dogs? Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. Copyright 2023 Animalytix LLC. Simparica may be better for small breeds, especially puppies under two pounds. Dognutrition.com is a participant in the Amazon Services LLC Associates Program. Your dog can still contract a tick borne disease because the drugs dont even repel the parasites. however, the following side effects are seen in less than 1 dog in 10, 000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8pounds or greater. I gave it to her at 4 and by 6 she had diarrhea. Usually most diarrhea will run its course within two to four days, although in some cases, it can last longer. Simparica trio for dogs: uses, dosage, safety, and side. What are the side effects of entyce for dogs? The medication is supposed to control the parasites that cause these seizures, including roundworms, hookworms, and fleas. One important similarity between these two medications is that they both protect dogs against heartworms, roundworms, hookworms, and fleas. Both medications are safe for pregnant dogs, although NexGard is a better choice for breeding dogs. The word ataxia means incoordination within the nervous system. A single oral dose of Simparica Trio was safe and highly efficacious against naturally occurring flea and tick infestations for 1 month on dogs. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea. Simparica Chewables for Dogs above 88 lbs (Red) 3 Pack is of $39.79 6 Pack is of $68.42. Simparica Trio resulted in 94.2% efficacy within 24 h of infestation for . THIS SERVICE AND DATA ARE PROVIDED "AS IS". Available for dogs of almost any size. A study in Science Direct adds that: The sarolaner molecule has unique structural features important for its potency and pharmacokinetic (PK) properties, including spiroazetidine and sulfone moieties. it helps to prevent ear mites, flea allergy dermatitis, tick bite fever, and anemia resulting from tick bite fever. Instead, it kills larvae, allowing your dog to avoid infection. As an Amazon Associate, we earn from qualifying purchases. Flea excrement is red and black in color, cylindrical, pellet or comma-shaped. Some of its competitors only offer protection against 4. Our dogs do not need these drugs, as there are other much safer methods to combat the problems that these drugs are supposed to combat but are in fact aggravating because of the horrible side effects. Some of the worst parasites that can infect your dogs are; It can be confusing remembering what medication your dog should take and when. Because Simparica kills ticks and fleas before they lay eggs, its safe for your pup during the spring, summer, and fall. Consult with your veterinarian as to the correct dosing schedule. It is important to note that heartworm tests may not appear for several months after treatment is finished. SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Vomiting, itching, lethargy, diarrhea, and lack of appetite are the most frequently reported adverse reactions. Also, its best to treat all pets in your household, not just one. Moxidectin is a semi-synthetic methoxime derivative of nemadectin which is a fermentation product of Streptomyces cyaneogriseus subspecies noncyanogenus. How long does it take NexGard or NexGard SPECTRA to kill fleas? Heavy tick infestation not only causes severe damage to the skin, but anemia, paralysis, and other complications can also result. The Simparica dosages last for 35 days, while the Nexgard doses last for 28. In a 10-day multi-center field study, SIMPARICA TRIO was effective against Toxocara canis and reduced fecal egg counts 99.2%. The all-new Simparica Trio chewable treatment is extremely safe for dogs of all breeds, except the following: Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Safe for puppies seven weeks and older. It is an advanced, swift working, and broad-spectrum treatment for dogs. It kills and eliminates fleas before they can lay eggs. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (Vss) was 2.4 L/kg and systemic clearance (CL) was 6.0mL/kg/hr. It is a yellow, water-insoluble crystalline salt of the tetrahydropyrimidine base and pamoic acid containing 34.7% base activity. . 1 x 5mg tablet for 2.8 to 5.5 pounds. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is concerning. This drug is effective at killing adult heartworms and the adjacent blood vessels. These signs usually resolve without treatment. . However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. How long do side effects last for Simparica Trio? Maddy is a rescue and having to force so many pieces down her throat takes a long time and it upsets her. It broke my heart to see the pain I put her through by giving her Simparica. The adipose tissue acts as a reservoir, allowing efficacy. Easy to apply at home. Flea allergy dermatitis tends to occur mostly in the late summer. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Learn more. Here are some of the most important information about the effectiveness of this drug;if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[300,250],'worlddogfinder_com-box-4','ezslot_3',140,'0','0'])};__ez_fad_position('div-gpt-ad-worlddogfinder_com-box-4-0');if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[300,250],'worlddogfinder_com-box-4','ezslot_4',140,'0','1'])};__ez_fad_position('div-gpt-ad-worlddogfinder_com-box-4-0_1');.box-4-multi-140{border:none!important;display:block!important;float:none!important;line-height:0;margin-bottom:7px!important;margin-left:auto!important;margin-right:auto!important;margin-top:7px!important;max-width:100%!important;min-height:250px;padding:0;text-align:center!important}. Will you do the same? Simparica is used to control flea and tick infestations in dogs. Side effects with Simparica are not common. SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. If you havent tried this on your dog then get it now from BudgetPetCare at discounted prices.