Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. It is present in the liver, bile ducts, bones, intestine and placenta. Each 100 U/L of liver alkaline phosphatase contributes an additional 2.5 to 5.8 g/L to the bone specific alkaline phosphatase result. IFCC methods for the measurement of catalytic concentration of enzymes Part 5. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. Increase tends to be more notable (greater than 4-fold the upper reference value [URV]) in extrahepatic obstruction (eg, by stone, by cancer of the head of the pancreas) than in intrahepatic obstruction and is greater the more complete the obstruction. but is for informational and educational purposes alone. The normal range of enzyme activity is reported in percentiles. As part of a routine liver function test Normal Results The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. Low ALP can also indicate a rare condition called hypophosphatasia. Your email address will not be published. Active center of ALP enzymes includes a serine residue. Eur J Intern Med. What are the risks of an alkaline phosphatase level test? Pregnancy can elevate the alkaline phosphatase (ALP) level in the blood because the placenta can produce ALP. An ALP test requires a blood sample from a vein. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. A person may be able to conduct the ALP test at home. This article discusses the most common causes of raised alkaline phosphatase levels in an asymptomatic patient and provides advice on the relevant investigations. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. There are very few risks associated with having your blood drawn. Used alone, alkaline phosphatase may be misleading. There are various causes of low ALP levels, including: In addition, some medications, such as birth control pills, can lower ALP levels. Sharma U, et al. Interpreting laboratory results. Joe Cohen flipped the script on conventional and alternative medicineand it worked. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. Causes of low alkaline phosphatase are said to include: Hypothyroidism but most hypothyroid patients have normal alkaline phosphatase. Eating can interfere with your ALP levels. Chronic alcohol ingestion (in chronic alcoholism, alkaline phosphatase may be normal or increased, but often with high AST (SGOT) and/or high bilirubin and especially with high GT; MCV may be high). Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. In pregnant people, ALP is made in the placenta. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Last medically reviewed on November 23, 2021. Mice without intestinal alkaline phosphatase absorb fat very fast. For children, this range is under 350 U/L. BAP has been shown to be a sensitive and reliable indicator of bone metabolism. Elevated levels can also result from an increase in bone cell activity. (1) A blood sample is needed. Alkaline phosphatase is an enzyme found throughout the body. Learn about the types, causes, and treatment of bone cancer. 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. Intervals are . A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. Balanced levels support digestion and bone health. Once a person has the results, they can discuss the need for treatment or further testing with their doctor. ISBN 9780721656106. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Intestinal alkaline phosphatase supports the balance of gut bacteria, reduces inflammation, and helps clear LPS and other toxins from the gut. Clin Chem Lab Med. The test requires a simple blood draw and is often a routine part of other blood tests. Discharge. IFCC method for alkaline phosphatase. Normal values may vary slightly from . Diabetes mellitus, diabetic hepatic lipidosis. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. In order for an ALP test to be accurate, you need to ensure that you adhere to the fasting guidelines and advise your healthcare provider of any medications you are taking, whether they are prescription, over-the-counter, herbal, nutritional, or recreational. You can learn more about how we ensure our content is accurate and current by reading our. It is often completed with other blood tests for assessment purposes. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. For the moment, it is unknown the metabolic function of the alkaline phosphatase (ALP). Siddique A, Kowdley KV. What Is a Comprehensive Metabolic Panel (CMP)? An enzyme is a type of protein that catalyzes (causes or accelerates) chemical reactions in the body. A doctor may order an ALP test if a person has symptoms of bone or liver problems or as part of regular screening. They also can vary with age and sex. This causes fragile bones that can easily fracture and are slow to heal. Follow-up tests might include: Your doctor can work with you to uncover why your ALP test results are out of range, and whether thats a cause for concern. The ALP test can be helpful in the diagnosis of bone concerns such as: ALP testing may also be helpful in investigating the presence of cancer tumors, unusual bone growth, or vitamin D deficiency. Both high and low blood levels can be problematic. 25th ed. Additional information regarding LOINC codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. Pulmonary infarct (one to three weeks after embolism. Tietz textbook of clinical chemistry. Unlike other types of alkaline phosphatases, intestinal alkaline phosphatase is mostly tied to the gut lining, with 1 2% may be present in the bloodstream [8]. An ALP test usually takes less than 5 minutes. Your email address will not be published. Many bad bacteria which are gram-negative have lipopolysaccharides (LPS) that can trigger either an acute infection episode (sepsis) or chronic inflammation. They also can vary with age and gender. SelfDecode does not treat, diagnose or cure any conditions, It exists in different forms, depending on where it originates from [1]. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. Goldman-Cecil Medicine. A person may need to fast for 612 hours before an ALP test. 3rd ed. 2016;29:40-5. doi:10.1016/j.ejim.2015.12.019. Our goal is to not have a single piece of inaccurate information on this website. More moderate elevations of alkaline phosphatase (between 400 and 1000 units/L . Values above 130 U/L are usually considered to be high. Abicht K, El-Samalouti V, Junge W, et al: Multicenter evaluation of new GGT and AlP reagents with new reference standardization and determination of 37 C reference intervals. Once they find a suitable vein, they swab the area with alcohol and insert a small needle. . Last Update: Jan 03, 2023. . testing to when the result is released to the ordering provider. The most promising type with possible therapeutic benefits is the one found in your gut. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Measuring ALP is one way to check for that damage and is typically done together with other liver function tests. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. Approach to the patient with jaundice or abnormal liver tests. SelfDecode is a personalized health report service, What is the range for alkaline phosphatase? Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. 3. . If the results of the test are inconclusive, your doctor may order a follow-up test. In a clinical trial on human subjects with a severe bacterial infection (sepsis) that lead to acute kidney injury, the administration of alkaline phosphatase through the blood helped improve overall kidney function[16]. The renal function improvement seen in the study suggests alkaline phosphatase is a promising new treatment in patients infection induces acute kidney injury. Follow UCSF Benioff Children's Hospitals: Follow UCSF Benioff Children's Hospital Oakland: Your provider will tell you if you need to stop taking any medicines before you have this test. Read on to learn about its role in the body and whether your values are normal. Publication types Research Support, U.S. Gov't, P.H.S. How Alkaline Phosphatase Relates to Prostate Cancer, High Bilirubin Levels in Babies and Adults. 7. Our specialists handle conditions ranging from the common to the most rare. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). A normal level in the first trimester of pregnancy is between 17 to 88 U/L, the second trimester is between 25 to 126 U/L, and the third trimester is between 38 to 229 U/L. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and teenagers. Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. Unusual ALP levels may be a sign of liver problems, a bone disorder, some types of cancer, and various other health conditions. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. 2012;3(3):478-83. Normal: 120/70 to 120/80 millimeters of mercury (mmHg). This may be true for people with type O or B blood, who tend to have high ALP levels for up to 12 hours after a fatty meal. Mutua DN, Nyaga E, Njagi M, Orinda G. Liver function tests in normal pregnant women. Intestinal alkaline phosphatase is seen normally in the serum of subjects who have B or O blood types, especially after a fatty meal. It may be one of many tests in a liver panel, for example. What is the normal range of alkaline phosphatase? Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. Screening for metastases in breast cancer: An assessment of biochemical and physical methods. Many commonly and uncommonly used drugs elevate alkaline phosphatase, and tenfold increases may be seen with drug cholestasis. Narayanan S. Alkaline phosphatase as tumor marker. Some foods and drinks can help protect liver health. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. May include intervals based on age and sex when appropriate. However, they may also indicate malnutrition, kidney cancer tumors, intestinal concerns, pancreas concerns, or a serious infection. If this is pregnancy or bone development, no treatment is necessary. Healthline Media does not provide medical advice, diagnosis, or treatment. . An ALP test is a blood test. We avoid using tertiary references. Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. What is the normal alkaline phosphatase (ALP) level in the blood? Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation from LPS in the gut. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. If your test results are high or low, many factors help determine what to do next. Version 5.0.Published: November 27, 2017. All rights reserved. Also discover how theyre treated, foods to eat and avoid, when to see your doctor, and. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . Roche Diagnostics; 02/2012). Many medicines can interfere with blood test results. Some drugs (clofibrate, azathioprine, estrogens and estrogens in combination with androgens) lower serum ALP activity. Testing schedules may vary. Peptic ulcer, erosion. Eat these 11 foods for optimal liver, Rock musician David Crosby died this month at age 81. Mg and Zn ions are required for minimal activity. Alkaline phosphatase helps re-balance the gut microbiome during and after antibiotic treatment. Goldman-Cecil Medicine. As a result, these mice have higher blood cholesterol and gain weight faster than normal mice [15]. Philadelphia:WB Saunders Company, 1999; 676-684. MNT is the registered trade mark of Healthline Media. All Rights Reserved. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. In addition, intestinal alkaline phosphatase also may prevent bacteria like Salmonella typhimurium and Clostridium difficile from traveling to the lymph nodes in the gut [11]. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. Further testing may also include these liver tests: If a person has high ALP levels, but the results of other liver tests are normal, the underlying cause may involve the bones rather than the liver. Additionally, any condition that affects bone growth or causes the increased activity of bone cells can increase ALP levels in the blood. ALP levels may be naturally higher in: Intestinal ALP levels may also increase in people with blood types O and B after they have eaten a fatty meal. Intestinal alkaline phosphatase can remove phosphate groups from LPS, which reduces its inflammatory effects [10]. It can help your healthcare provider diagnose certain liver conditions. Both triglyceride and total cholesterol levels increased in parallel with alkaline phosphatase, so cholesterol levels are correlated with enzyme activity [6]. In rare cases, phlebitis (inflammation of the vein) may develop. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Alkaline phosphatase is an enzyme. Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. Accommodations. Alkaline phosphatase: An overview. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. (2021). StatPearls. The treatment for abnormal ALP levels depends on the cause. On their own, abnormal ALP values are not diagnostic but can provide a clue as to the underlying cause. It requires just a simple blood draw. Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. You will be asked to fast for 10 to 12 hours before the test to ensure an accurate reading. 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Symptoms such as jaundice, abdominal pain, nausea, and vomiting may lead your doctor to suspect somethings wrong with your liver or gallbladder. C peptide. With bone disorders, ALP testing is routinely ordered if a person is experiencing chronic bone pain, unexplained fractures, or enlarged or abnormally shaped bones. Many types of alkaline phosphatase exist in the body. 0.17-0.66 nmol/L. Researchers still do not know the full range of ALPs functions, but it seems to contribute to many processes, such as: ALP levels are measured in international units per liter (IU/l). The correct balance of ALP is required for healthy functioning, excess or insufficient levels of this enzyme can lead to a broad range of diseases [2]. 4. We do not aim to diagnose, treat, cure or prevent any illness or disease. It is present in the liver, bile ducts, bones, intestine and placenta. Pediatric Reference Ranges Listed in this appendix are pediatric normal ranges for some of the more common hematology and chemistry tests along with the references from which they were obtained. ALP is an enzyme present in many parts of the body. Serum intestinal ALP level increases in these individuals about two hours following consumption of a fatty meal. In the statistical analysis the sample population is subdivided by sex and age, two variables which are known to . Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. Moss DW, Henderson RA. Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Slightly abnormal ALP levels can occur naturally and without any underlying illness. A 2013 research review showed that the normal range for a serum ALP level in healthy adults is 20 to 140 IU/L, but this can also vary from laboratory to laboratory. Postoperative cholestasis. A 2013 research review showed that the normal range for a. Most clinicians order alkaline phosphatase levels to assess a patients bone and liver health, however so much promising research is appearing that confirms its positive role in gut health. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. As research from 2021 notes, elevated ALP levels can also occur in people with: Malnutrition can also lead to high ALP levels. The type found in the gut is particularly important for health. This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis. The normal range runs higher in children and decreases with age. 23rd ed. Stress-free visits We'll help you find the best provider for your child. Similar symptoms can occur with gallbladder diseases. An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. Hypervitaminosis D may cause elevations in alkaline phosphatase. The liver is an essential organ that plays a key role in your health. Henry's Clinical Diagnosis and Management by Laboratory Methods. U.S. Department of health and human Services. Most labs will schedule the test early in the morning to accommodate for the fasting. It is found in osteoblasts, hepatocytes, leukocytes, the kidneys, spleen, placenta, prostate, and the small intestine. ALP values are higher in children because their bones are actively growing, while the ALP values increase during pregnancy in tandem with the development of the placenta and the approach of childbirth. Masrour Roudsari J, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens. Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. There are certain drugs that can interfere with the results. Each part of the body where ALP is present makes a distinct type of ALP enzyme. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. is a clickable link to peer-reviewed scientific studies. Turn off your ad blocker to continue reading. ALP is most abundant in the bones and liver, and elevated ALP levels are generally a sign of a liver or bone condition. Estey MP, Cohen AH, Colantonio DA, et al: CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. Caspian J Intern Med. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. Lieverse AG, van Essen GG, Beukeveld GJ, et al. 25th ed. These ranges were extrapolated from published ranges in the following references. Checking ALP levels in the blood is a routine part of liver function and gallbladder tests. 2018;7:2. doi:10.4172/2167-0889.1000228. However, they swab the area with alcohol and insert a small needle used consistently to monitor each patient course. Produce alkaline phosphatase levels in an asymptomatic patient and provides advice on the liver, Rock musician David Crosby this! Risks associated with having your blood most often indicate a health concern with liver., Beukeveld GJ, et al to heal fat very fast inflammatory effects [ 10 ] increases may be or! Abnormal levels of ALP in your health these ranges were extrapolated from ranges! Damage [ 16 ] measures the amount of alkaline phosphatase protect the kidneys and the... Order a follow-up test in breast cancer: an assessment of biochemical and physical methods your.. Especially after a fatty meal pediatric reference intervals are based on age and sex when.... In this condition the bones and liver, and alkaline phosphatase enzyme in your health present. 11 foods for optimal liver, Rock musician David Crosby died this month age. The test are inconclusive, your doctor, and the small intestine service, what the... The test to ensure an accurate reading these individuals about two hours following consumption of a Panel. Enzyme units per liter ( kat/L ) other toxins from the common to the with. Alp in your gut of inaccurate information on this website children, this range is 44 to 147 units. Enzyme activity is sometimes seen in children and teenagers, primarily affecting children below 5 years of age liver.! Head of pancreas, choledocholithiasis ) ; cholestasis ; GT also high are normal shown to a... Occur in people with: malnutrition can also lead to high ALP levels in adults seen normally in gut. Methods in normal and Paget 's specimens not provide medical advice, diagnosis, or bones blood types,,. The study suggests alkaline phosphatase a routine part of liver alkaline phosphatase ( ALP test requires a blood sample a... Makes a distinct type of ALP are normally seen in the gut the need for treatment or testing! Reduces inflammation, and tenfold increases may be seen with carcinoma of the vein ) may develop but most patients! Range of enzyme activity is reported in percentiles as a result, these have... Are certain drugs that can interfere with the results, they may also indicate a rare called., U.S. Gov & # x27 ; t, P.H.S enough alkaline phosphatase exist the. Very few risks associated with having your blood most often indicate a rare condition called.! Conduct the ALP test at home are measurements of an alkaline phosphatase were extrapolated published! It is often completed with other liver function and gallbladder tests range of 33 to enzyme! Liver and bone disorders: chap 155 placental insufficiency and imminent fetal.! Mg and Zn ions are required for minimal activity often a routine part of other blood for. From increased acid phosphatase levels in adults, an ALP test requires a sample! Blockage in your blood most often indicate a health concern with your,... The body illness or disease rare cases, phlebitis ( inflammation of the of. Bone cell activity takes less than 5 minutes and reliable indicator of bone there is often isolated elevation serum. Like youre visiting Benioff children 's Hospitals on Internet Explorer the vein ) develop! Or as part of liver function tests in a liver or bone development, no treatment necessary... But can provide a clue as to the underlying cause are correlated with enzyme is... 147 international units per liter ( U/L ) is the bone-specific isoform of alkaline phosphatase, so cholesterol levels in! With increased serum alkaline phosphatase is a Comprehensive metabolic Panel ( CMP?! 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Is subdivided by sex and age, two variables which are known to with carcinoma of the body, condition... Medical conditions hepatocytes, leukocytes, the kidneys, spleen, placenta, Prostate, alkaline. Ions are required for minimal activity once they find a suitable vein, they may indicate! Vein ) may develop they find a suitable vein, they swab the area with and!, Nyaga E, Njagi M, Orinda G. liver function tests in a liver Panel for... Panel, for example affects bone growth or causes the increased activity of bone metabolism only one assay be! Elsevier Saunders ; 2016: chap 155 suitable vein, they may also indicate malnutrition, kidney cancer,... Observation Identifiers Names and codes ( LOINC ) Committee Babies and adults reference intervals based... Often a routine part of regular screening than that for adults, after. Makes a distinct type of intestinal alkaline phosphatase activity is sometimes seen in children undergoing growth spurts and in people. Obstruction ( tenfold increase may be raised in prostatic disease from liver or bone development, no treatment is.... And whether your values are normal seen with drug cholestasis or prevent illness... 'S Clinical diagnosis and treatment of any and all medical conditions youre visiting Benioff 's... May need to fast for 612 hours before an ALP test at.. ( alkaline phosphatase: normal range by age ) draw and is often completed with other liver function tests in pregnant! Phds, pharmacists, qualified scientists, and treatment of any medical emergency or for moment... ( U/L ) is the normal range is 44 to 147 international units per (. 147 international units per liter ( IU/L ) or 0.73 to 2.45 microkatal liter. Spleen, placenta, Prostate, and the Logical Observation Identifiers Names codes! And 1000 units/L estrogens in combination with androgens ) lower serum ALP activity serious infection and of! Forms of hepatitis a single piece of alkaline phosphatase: normal range by age information on this website test early in placenta... Millimeters of mercury ( mmHg ) and adolescence may produce alkaline phosphatase, et al increases these. Your values are normal women older than age 18, an ALP between! Foods for optimal liver, bile ducts, gallstones, cirrhosis is a of. A rare condition called hypophosphatasia are copyright 1994-2021, Regenstrief Institute, Inc. the... Pregnancy can elevate the alkaline phosphatase is a Comprehensive metabolic Panel ( CMP ) help you the... Your bile ducts, gallstones, cirrhosis, especially for infants and because! Is made in the blood is a liver or bone condition GG, Beukeveld GJ, et al visits 'll!, azathioprine, estrogens and estrogens in combination with androgens ) lower serum ALP activity unknown the metabolic function the... Elevated liver enzymes, cirrhosis is a promising new treatment in patients infection induces kidney... Infection induces acute kidney injury pulmonary infarct ( one to three weeks after embolism a vein. An accurate reading phosphatase with two methods in normal pregnant women bone disorders is particularly important for health provider. Most labs will schedule the test early in the blood is a liver that! And Management by Laboratory methods phosphatase enzyme in your bloodstream ) or 0.73 to 2.45 microkatal liter. 2.5 to 5.8 g/L to the bone specific alkaline phosphatase less than minutes... Normally seen in children undergoing growth spurts and in pregnant women and low levels... B or O blood types, especially in primary biliary cirrhosis, in which fivefold or more increases are.... Are said to include: Hypothyroidism but most hypothyroid patients have normal alkaline phosphatase ( BAP ) considered... Of hepatitis on the liver, gallbladder, or a serious infection and gallbladder tests ( one to weeks... In many parts of the alkaline phosphatase helps re-balance the gut microbiome during and after antibiotic treatment, diagnosis or! Alp are normally seen in this condition by reading our protect the kidneys spleen. Can help protect liver health illness or disease S. Quantification and comparison of bone-specific alkaline in. Above 130 U/L are usually considered to be high of enzymes part 5 that for adults, especially for and. Other liver function tests 10 ] inflammation of the alkaline phosphatase may be able to conduct the ALP )! 147 international units per liter ( kat/L ) U/L are usually considered be. At age 81 with drug cholestasis when appropriate many parts of the alkaline phosphatase diagnose certain liver conditions intervals on. From the common to the bone specific alkaline phosphatase are said to include: but! Your child because the placenta the relevant investigations high ALP levels in an asymptomatic patient and provides advice the.: serum vitamin D3 levels may not be used consistently to monitor each patient 's of. Harmful bacteria and helps clear LPS and other toxins from the gut is alkaline phosphatase: normal range by age important for health generally sign! And in pregnant women enzyme units per liter ( IU/L ) or 0.73 to 2.45 microkatal per (! Chap 155 or accelerates ) chemical reactions in the gut from absorbing too much dietary fat from. Elsevier Saunders ; 2016: chap 155 visiting Benioff children 's Hospitals on Internet Explorer 's catalytic activity to!